| Identification | Back Directory | [Name]
Benzoic acid, 5-[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-2-[(4-methoxybenzoyl)amino]- | [CAS]
1242862-71-0 | [Synonyms]
FUBP1-IN-2
Benzoic acid, 5-[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-2-[(4-methoxybenzoyl)amino]- | [Molecular Formula]
C26H26ClN3O4 | [MOL File]
1242862-71-0.mol | [Molecular Weight]
479.96 |
| Hazard Information | Back Directory | [Uses]
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1]. | [References]
[1] Dobrovolskaite A, et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. J Med Chem. 2022 Nov 24;65(22):15391-15415. DOI:10.1021/acs.jmedchem.2c01350 |
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