| Chemical Properties | Back Directory | [Boiling point ]
741.131±70.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.421±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
8.345±0.20(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport[1]. | [References]
[1] Pavlinov I, et al. Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I. J Am Chem Soc. 2020 May 6;142(18):8174-8182. DOI:10.1021/jacs.9b12705 |
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