| Identification | Back Directory | [Name]
1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one | [CAS]
1243148-19-7 | [Synonyms]
Z36
Z36 >=98% (HPLC)
(Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one
1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one | [Molecular Formula]
C23H24FN3O2 | [MDL Number]
MFCD20527328 | [MOL File]
1243148-19-7.mol | [Molecular Weight]
393.45 |
| Chemical Properties | Back Directory | [Boiling point ]
565.8±50.0 °C(Predicted) | [density ]
1.273±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
16.02±0.30(Predicted) | [color ]
light yellow to dark yellow | [InChI]
1S/C23H24FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h5-8,11-14,25H,4,9-10H2,1-3H3/b20-11- | [InChIKey]
CQNOITUXWKRVMB-JAIQZWGSSA-N | [SMILES]
COc1ccc2[nH]cc(\C=C3/C(=O)N(CCCN(C)C)c4ccc(F)cc34)c2c1 |
| Hazard Information | Back Directory | [Uses]
Z36 may be used to study cell signaling th at results in autophagy. | [Biological Activity]
Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.''Z36 is a Bcl-XL inhibitor th at induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors th at induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|