| Identification | Back Directory | [Name]
3-(2-(2-Azidoethoxy)ethoxy)prop-1-yne | [CAS]
1245006-63-6 | [Synonyms]
Azido-PEG2-propargyl
3-(2-(2-Azidoethoxy)ethoxy)prop-1-yne
1-Propyne, 3-[2-(2-azidoethoxy)ethoxy]- | [Molecular Formula]
C7H11N3O2 | [MDL Number]
MFCD24457814 | [MOL File]
1245006-63-6.mol | [Molecular Weight]
169.18 |
| Hazard Information | Back Directory | [Uses]
Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-propargyl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024 |
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