| Identification | Back Directory | [Name]
BCI | [CAS]
1245792-51-1 | [Synonyms]
BCI
(E)-BCI
BCI - NSC 150117
1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-, (2E)- | [Molecular Formula]
C22H23NO | [MOL File]
1245792-51-1.mol | [Molecular Weight]
317.42 |
| Questions And Answer | Back Directory | [Description]
BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively. |
| Hazard Information | Back Directory | [Uses]
BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2]. | [Definition]
ChEBI: (2E)-2-benzylidene-3-(cyclohexylamino)indan-1-one is a 2-benzylidene-3-(cyclohexylamino)indan-1-one in which the double bond has E configuration. An inhibitor of the dual specificity phosphatase 6 (Dusp6). It has a role as an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and an apoptosis inducer. | [References]
[1] Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45. DOI:10.1002/cbic.201402000
[2] Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681. DOI:10.1007/s10753-018-0924-2 |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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