| Identification | Back Directory | [Name]
Pyrotinib Racemate | [CAS]
1246089-97-3 | [Synonyms]
Pyrotinib Racemate
2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-(1-methyl-2-pyrrolidinyl)- | [Molecular Formula]
C32H31ClN6O3 | [MDL Number]
MFCD31619255 | [MOL File]
1246089-97-3.mol | [Molecular Weight]
583.08 |
| Chemical Properties | Back Directory | [Boiling point ]
775.5±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 1.81 mg/mL (3.10 mM) | [form ]
Solid | [pka]
13.10±0.43(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(Rac)-Pyrotinib ((Rac)-SHR-1258) is the racemic form of Pyrotinib (HY-104065). Pyrotinib is a potent and selective dual EGFR/HER2 receptor inhibitor. | [References]
[1] Li X, et al. Discovery and development of Pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X. DOI:10.1016/j.ejps.2017.01.021 |
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