| Identification | Back Directory | [Name]
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-8-fluoro-4,9-dihydroxy-, (4S)- | [CAS]
124623-00-3 | [Synonyms]
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-8-fluoro-4,9-dihydroxy-, (4S)- | [Molecular Formula]
C22H19FN2O5 | [MOL File]
124623-00-3.mol | [Molecular Weight]
410.4 |
| Hazard Information | Back Directory | [Uses]
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells[1]. | [References]
[1] Yoshikawa M, et al. Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells[J]. International journal of cancer, 2004, 110(6): 921-927. DOI:10.1002/ijc.20216 |
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