| Identification | Back Directory | [Name]
N-nervonoyl-1-deoxysphingosine (M18:1/24:1) | [CAS]
1246298-58-7 | [Synonyms]
N-C24:1-deoxysphingosine
N-nervonoyl-1-deoxysphingosine (M18
C24:1 1-Deoxyceramide (m18:1/24:1(15Z))
N-nervonoyl-1-deoxysphingosine (M18:1/24:1)
N-NERVONOYL-1-DEOXYSPHINGOSINE (M18:1/24:1);N-C24:1-DEOXYSPHINGOSINE
15-Tetracosenamide, N-[(1S,2R,3E)-2-hydroxy-1-methyl-3-heptadecen-1-yl]-, (15Z)- | [Molecular Formula]
C42H81NO2 | [MDL Number]
MFCD22416691 | [MOL File]
1246298-58-7.mol | [Molecular Weight]
632.1 |
| Chemical Properties | Back Directory | [Boiling point ]
717.2±53.0 °C(Predicted) | [density ]
0.886±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: >20 mg/ml; DMSO: >20 mg/ml; Ethanol: >30mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml; PBS (pH 7.2): <50μg/ml | [form ]
A crystalline solid | [pka]
13.78±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is a very long-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(4E)) backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis. | [Uses]
C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) (C24:1(15Z) 1-Deoxyceramide) is a lipid molecule, which is composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro[1]. | [References]
[1] Hannich JT, et al., Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients. Acta Physiol (Oxf). 2021 May;232(1):e13610. DOI:10.1111/apha.13610 |
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