| Identification | Back Directory | [Name]
MPLA (synthetic) Sterile Solution | [CAS]
1246298-63-4 | [Synonyms]
MPLA
GLA (PHAD)
MPLA (PHAD)
Glycopyranoside lipid A
Glucopyranosyl Lipid Adjuvant
MPLA (synthetic) Sterile Solution
Monophosphoryl Lipid A (Synthetic) (PHADTM)
Monophosphoryl Lipid A (Synthetic) (PHAD™
MONOPHOSPHORYL LIPID A (SYNTHETIC) (PHAD™);MPLA (PHAD) | [Molecular Formula]
C96H184N3O22P | [MDL Number]
MFCD00920789 | [MOL File]
1246298-63-4.mol | [Molecular Weight]
1763.47 |
| Hazard Information | Back Directory | [Uses]
Monophosphoryl Lipid A, or GLA-SE, is a synthetic toll-like receptor 4 agonist which enhances T-cell responses to influenza vaccine in older adults. | [Biological Activity]
Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. MPLA used in vaccination improves B cell and T cell-mediated immunity. | [in vivo]
The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice[2]. | [IC 50]
TLR4 | [References]
[1] N QURESHI. Monophosphoryl lipid A obtained from lipopolysaccharides of Salmonella minnesota R595. Purification of the dimethyl derivative by high performance liquid chromatography and complete structural determination.[J]. The Journal of Biological Chemistry, 1985, 260 9: 5271-5278.
[2] STACIE L LAMBERT. Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid A.[J]. PLoS ONE, 2012: e51618. DOI: 10.1371/journal.pone.0051618
[3] MAURICIO A ARIAS. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.[J]. PLoS ONE, 2012: e41144. DOI: 10.1371/journal.pone.0041144
[4] SUSAN L BALDWIN. The importance of adjuvant formulation in the development of a tuberculosis vaccine.[J]. Journal of immunology, 2012, 188 5: 2189-2197. DOI: 10.4049/jimmunol.1102696 |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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