| Identification | Back Directory | [Name]
3-Quinolinecarboxamide, 1,2-dihydro-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2-oxo- | [CAS]
1246668-32-5 | [Synonyms]
3-Quinolinecarboxamide, 1,2-dihydro-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2-oxo- | [Molecular Formula]
C16H12N2O5 | [MOL File]
1246668-32-5.mol | [Molecular Weight]
312.28 |
| Hazard Information | Back Directory | [Description]
PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines. |
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