| Identification | Back Directory | [Name]
methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride | [CAS]
1248-42-6 | [Synonyms]
Pitophenone hydrochloride
Baralgin Ketone Hydrochloride
PITOFENONEHYDROCHLORIDE(FORR&DONLY)
methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride
methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride
2-[4-(2-piperidinoethoxy)benzoyl]benzoic acid methyl ester hydrochloride
methyl 2-[4-(2-piperidin-1-ylethoxy)phenyl]carbonylbenzoate hydrochloride
Benzoic acid,2-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-, methyl ester, hydrochloride (1:1) | [EINECS(EC#)]
214-999-8 | [Molecular Formula]
C22H26ClNO4 | [MDL Number]
MFCD01661944 | [MOL File]
1248-42-6.mol | [Molecular Weight]
403.899 |
| Chemical Properties | Back Directory | [Melting point ]
169-170°C | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white | [Water Solubility ]
H2O: 2mg/mL, clear | [InChI]
1S/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H | [InChIKey]
ZRFIFDFEDPJBII-UHFFFAOYSA-N | [SMILES]
[Cl-].N3(CCCCC3)CCOc1ccc(cc1)C(=O)c2c(cccc2)C(=O)OC.[H+] |
| Hazard Information | Back Directory | [Description]
Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE; Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively). It inhibits acetylcholine-induced contractions of isolated guinea pig ileum when used at a concentration of 2.5 μM. | [Chemical Properties]
White Solid | [Uses]
Diclofenac and its combination with Pitofenone and Fenpiverinium | [IC 50]
AChE | [References]
[1] N S PUNEKAR A V K. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound.[J]. Biotechnology and applied biochemistry, 1991, 14 3: 378-382.
[2] SHRINIVAS K KULKARNI. Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.[J]. Indian journal of experimental biology, 2004, 42 6: 567-569.
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J & K SCIENTIFIC LTD.
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Finetech Industry Limited
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Xi'an MC Biotech, Co., Ltd.
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