| Identification | Back Directory | [Name]
4-Oxazolecarboxylic acid, 2-(4-methoxyphenyl)-5-methyl-, ethyl ester | [CAS]
124811-87-6 | [Synonyms]
CIB-3B
Anticancer agent 73
4-Oxazolecarboxylic acid, 2-(4-methoxyphenyl)-5-methyl-, ethyl ester | [Molecular Formula]
C14H15NO4 | [MOL File]
124811-87-6.mol | [Molecular Weight]
261.27 |
| Chemical Properties | Back Directory | [Melting point ]
79-80 °C | [Boiling point ]
383.9±52.0 °C(Predicted) | [density ]
1.159±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-0.38±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1]. | [in vivo]
Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) attenuates the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice[1] | [References]
[1] Peng T, et al. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem. 2022 Jun 13. DOI:10.1021/acs.jmedchem.2c00189 |
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