| Identification | Back Directory | [Name]
2,4-Pyrimidinediamine, N2-[4-(diethylamino)-1-methylbutyl]-N4-[2-(1H-indol-3-yl)ethyl]-6-methyl- | [CAS]
1249398-09-1 | [Synonyms]
AZA197
AZA-197
AZA 197
2,4-Pyrimidinediamine, N2-[4-(diethylamino)-1-methylbutyl]-N4-[2-(1H-indol-3-yl)ethyl]-6-methyl- | [Molecular Formula]
C24H36N6 | [MDL Number]
MFCD28160334 | [MOL File]
1249398-09-1.mol | [Molecular Weight]
408.58 |
| Chemical Properties | Back Directory | [Boiling point ]
625.4±65.0 °C(Predicted) | [density ]
1.133±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
17.17±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
AZA197 is a selective Cdc42 inhibitor. It acts by suppressing primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. | [Uses]
AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts[1]. | [References]
[1] Zins K, et al. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med. 2013 Nov 27;11:295. DOI:10.1186/1479-5876-11-295 |
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