| Identification | Back Directory | [Name]
3,5,7,9-Tridecatetraen-2-one,1,1,1-trichloro-4-hydroxy-11-methyl-, (3Z,5E,7E,9E,11S)- | [CAS]
124958-29-8 | [Synonyms]
neocarzilin A
3,5,7,9-Tridecatetraen-2-one,1,1,1-trichloro-4-hydroxy-11-methyl-, (3Z,5E,7E,9E,11S)- | [Molecular Formula]
C14H17Cl3O2 | [MOL File]
124958-29-8.mol | [Molecular Weight]
323.64 |
| Chemical Properties | Back Directory | [Boiling point ]
381.6±42.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
8.34±0.60(Predicted) | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Uses]
Neocarzilin A (NCA) reduces BST-2 levels via lysosomal degradation. Neocarzilin A has antimigratory and antiproliferative effects on cancer cells. Neocarzilin A inhibits cancer cell migration via irreversible binding to the synaptic vesicle membrane protein VAT-1[1][2]. | [References]
[1] Josef Braun, et al. Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR. JACS Au 2024. |
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