| Identification | Back Directory | [Name]
caramiphen hydrogen edisilate | [CAS]
125-86-0 | [Synonyms]
Ethanedisulfonate
BANIDACEBXZGNK-UHFFFAOYSA-N
Caramiphen ethanedisulfonate
caramiphen hydrogen edisilate
2-diethylaminoethyl 2-phenylcyclopentane-1-carboxylate
2-phenylcyclopentanecarboxylic acid 2-diethylaminoethyl ester
Bis[1-(carbo-β-diethylaminoethoxy)-1-phenylcyclopentane]ethanedisulfonate | [EINECS(EC#)]
204-759-0 | [Molecular Formula]
2C18H27NO2.C2H6O6S2 | [MDL Number]
MFCD00242609 | [MOL File]
125-86-0.mol | [Molecular Weight]
769.028 |
| Hazard Information | Back Directory | [Chemical Properties]
White or off-white crystalline powder. Melting point 115-116°C. Soluble in water and ethanol. Hygroscopic, odorless, bitter. | [Originator]
Panparnit,Geigy,US,1949 | [Uses]
Bis[1-(carbo-β-diethylaminoethoxy)-1-phenylcyclopentane]ethanedisulfonate is an anticholinergic and antiglutamatergic drug, which has also found use as an antidote against oragnophosphate poisoning. | [Manufacturing Process]
20.8 parts of 1-phenylcyclopentyl-1-carboxylic acid chloride, obtained from
the acid (cf. Am. Soc. 1934, 56, 715) by means of thionyl chloride, are
dissolved in 250 parts by volume of absolute ether, then, while stirring and
cooling with a mixture of common salt and ice a solution of 12 parts of
diethylaminoethanol in 50 parts by volume of absolute ether is allowed to
drop there into, the temperature being maintained below 0°C, whereupon
stirring is continued during 2 hours at room temperature. The whole is then
twice shaken out with water and once with diluted hydrochloric acid, the
combined aqueous solutions are made alkaline with a potassium carbonate
solution and shaken out with ether. The ethereal solution is washed with
water, dried over potassium carbonate and the solvent is distilled off. The base
boils at a pressure of 0.07 mm at 112°C to 115°C.
The base may then be converted to the hydrochloride or to the
ethanedisulfonic acid salt (edisylate). | [Therapeutic Function]
Antitussive |
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