| Identification | Back Directory | [Name]
LRE1 | [CAS]
1252362-53-0 | [Synonyms]
LRE1
LRE1 - RU-0204277
LRE1 >=98% (HPLC)
2,4-Pyrimidinediamine, 6-chloro-N4-cyclopropyl-N4-(2-thienylmethyl)- | [Molecular Formula]
C12H13ClN4S | [MDL Number]
MFCD23148480 | [MOL File]
1252362-53-0.mol | [Molecular Weight]
280.78 |
| Chemical Properties | Back Directory | [Boiling point ]
532.6±60.0 °C(Predicted) | [density ]
1.496±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
Solid | [pka]
4.32±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
PDWZXKSZLRVSEH-UHFFFAOYSA-N | [SMILES]
ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1 |
| Hazard Information | Back Directory | [Description]
T15787, also known as LRE1, is a novel specific and allosteric inhibitor of soluble adenylyl cyclase (sAC), binding to the bicarbonate activator binding site and inhibiting sAC via a unique allosteric mechanism, preventing sAC-dependent processes in cellular and physiological systems. | [Uses]
LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase. | [References]
[1] Ramos-Espiritu L, et al. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol. 2016 Oct;12(10):838-44. DOI:10.1038/nchembio.2151 |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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