| Identification | Back Directory | [Name]
GB-110 | [CAS]
1252806-70-4 | [Synonyms]
GB-110
L-Isoleucinamide, 3-cyclohexyl-N-(5-isoxazolylcarbonyl)-L-alanyl-N-[[3-[[4-(aminomethyl)-1-piperidinyl]carbonyl]phenyl]methyl]- | [Molecular Formula]
C33H48N6O5 | [MDL Number]
MFCD32197192 | [MOL File]
1252806-70-4.mol | [Molecular Weight]
608.77 |
| Hazard Information | Back Directory | [Description]
GB110 is a Novel potent non-peptide PAR2 agonist. | [Uses]
GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM[1]. | [IC 50]
PAR2: .28 μM (EC50) | [References]
[1] Barry GD, et al. Novel agonists and antagonists for human protease activated receptor 2. J Med Chem. 2010 Oct 28;53(20):7428-40. DOI:10.1021/jm100984y
[2] Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23. DOI:10.1111/j.1476-5381.2011.01610.x |
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