| Identification | Back Directory | [Name]
Mito-apocynin (C11) | [CAS]
1254044-38-6 | [Synonyms]
Mito-apocynin (C11)
Mito apocynin (C11),Mitoapocynin (C11),Mito-apocynin (C-11)
(11-((4-Hydroxy-3-methoxybenzoyl)oxy)undecyl)triphenylphosphonium bromide | [Molecular Formula]
C37H44BrO4P | [MDL Number]
MFCD32708521 | [MOL File]
1254044-38-6.mol | [Molecular Weight]
663.63 |
| Hazard Information | Back Directory | [Uses]
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function[1]. | [in vivo]
Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice[1]. | Animal Model: | LRRK2R1441G mice[1] | | Dosage: | 3 mg/kg | | Administration: | Oral gavage; 3x/wk from 3 months of age until 15 months | | Result: | Markedly improved the coordinated motor function and olfactory function.
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| [References]
[1] Dranka BP, et al. A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. Neurosci Lett. 2014 Nov 7;583:159-64. DOI:10.1016/j.neulet.2014.09.042 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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