| Identification | Back Directory | [Name]
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN-OH | [CAS]
125441-00-1 | [Synonyms]
AC-HIRUDIN (54-65) (SULFATED)
ACETYL-HIRUDIN (54-65) (SULFATED)
acetyl-[tyr(so3h)63]-hirudin fragment 54-65
N-acetyl-(tyr(so3H)63)-hirudin *fragment 54-65
N-ACETYL-HIRUDIN AC-[TYR(SO3H)63]-FRAGMENT 54-65
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN-OH
ACETYL-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR[SO3H]-LEU-GLN
Acetyl-Hirudin (54-65) (sulfated) Ac-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln-OH
L-Glutamine,N2-[N-[N-[N-[N-[1-[N-[N-[N-[N-[N-(N-acetylglycyl)-L-α-aspartyl]-L-phenylalanyl]-L-α-glutamyl]-L-α-glutamyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]- | [Molecular Formula]
C68H95N13O29S | [MDL Number]
MFCD00076566 | [MOL File]
125441-00-1.mol | [Molecular Weight]
1590.62 |
| Chemical Properties | Back Directory | [density ]
1.416±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [pka]
-4.17±0.18(Predicted) | [Sequence]
Ac-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-{Try(SO3H)}-Leu-Gln |
| Hazard Information | Back Directory | [Uses]
Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1]. | [References]
[1] J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9. DOI:10.1074/jbc.272.13.8243 |
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