| Identification | Back Directory | [Name]
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)- | [CAS]
1254979-66-2 | [Synonyms]
JNJ46356479
JNJ-46356479
JNJ 46356479
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1-piperazinyl]methyl]-8-(trifluoromethyl)- | [Molecular Formula]
C22H22F5N5 | [MDL Number]
MFCD30530740 | [MOL File]
1254979-66-2.mol | [Molecular Weight]
451.44 |
| Hazard Information | Back Directory | [Description]
JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256. JNJ-46356479 is in vivo active, sw-EEG at 3mg/kg, p.o. JNJ-46356479 represents a more balanced profile that offers a significant improvement on the druglike attributes compared to previously reported leads. | [Uses]
JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo[1]. | [References]
[1] Cid JM, et al. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM). J Med Chem. 2016;59(18):8495-8507. DOI:10.1021/acs.jmedchem.6b00913 |
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