ChemicalBook--->CAS DataBase List--->1254980-38-5

1254980-38-5

Request For Quotation
1254980-38-5 Structure

1254980-38-5 Structure
IdentificationBack Directory
[Name]

JNJ-46281222
[CAS]

1254980-38-5
[Synonyms]

JNJ-46281222
JNJ 46281222,JNJ46281222
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-8-(trifluoromethyl)-
[Molecular Formula]

C23H25F3N4
[MDL Number]

MFCD32689436
[MOL File]

1254980-38-5.mol
[Molecular Weight]

414.47
Chemical PropertiesBack Directory
[density ]

1.35±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

3.72±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].
[IC 50]

mGluR2: 1.7 nM (Kd)
[References]

[1] Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600. DOI:10.1111/bph.13390
1254980-38-5 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Website: https://www.targetmol.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Website: http://www.shyuanye.com
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Website: www.bio-fount.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Website: www.weikeqi-biotech.com/
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Tel: 51288865780
Website: www.biosynth.com
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Website: www.zzsrm.com
Tags:1254980-38-5 Related Product Information