| Identification | Back Directory | [Name]
1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide | [CAS]
1255516-86-9 | [Synonyms]
MS-1020
MS-1020 >=98% (HPLC)
1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide
1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide
2-Naphthalenecarboxamide, 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]- | [Molecular Formula]
C21H18N2O3 | [MDL Number]
MFCD21363377 | [MOL File]
1255516-86-9.mol | [Molecular Weight]
346.38 |
| Hazard Information | Back Directory | [Description]
MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM. It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death. | [Uses]
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1]. | [IC 50]
JAK3 | [References]
[1] Kim BH, et al. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010 Jan;148(1):132-43. DOI:10.1111/j.1365-2141.2009.07925.x |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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Creative Enzymes
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1-516-855-7709 |
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www.creative-enzymes.com |
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