| Identification | Back Directory | [Name]
UNC 0638 | [CAS]
1255517-77-1 | [Synonyms]
4-QuinazolinaMine, 2-cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-, hydrate
2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-Quinazolinamine hydrate (1:1)
4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-, hydrate (1:1) | [Molecular Formula]
C30H49N5O3 | [MDL Number]
MFCD22208587 | [MOL File]
1255517-77-1.mol | [Molecular Weight]
527.75 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
off-white | [InChIKey]
LLJGACAJGYXBTL-UHFFFAOYSA-N | [SMILES]
O.COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN4CCCC4)C5CCCCC5 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral
Aquatic Chronic 4 |
| Hazard Information | Back Directory | [Uses]
UNC 0638 is a useful intermediate. | [Definition]
ChEBI: 2-cyclohexyl-6-methoxy-N-(1-propan-2-yl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine is a member of quinazolines. | [Biological Activity]
UNC0638 hydrate is a histone methyltransferase (HMT) inhibitor. UNC0638 shows selectivity for G9a (EHMT2) and GLP (EHMT1) methyltransferaseswhich catalyze the methylation of lysine 9 of histone 3 (H3K9) as well as other non-histone substrates. For full characterization detailsplease visit the UNC0638 probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targetsvisit sigma.com/sgc |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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