| Identification | Back Directory | [Name]
Isoflucypram | [CAS]
1255734-28-1 | [Synonyms]
isoflucypram
1H-Pyrazole-4-carboxamide, N-[[5-chloro-2-(1-methylethyl)phenyl]methyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl- | [Molecular Formula]
C19H21ClF3N3O | [MOL File]
1255734-28-1.mol | [Molecular Weight]
399.84 |
| Chemical Properties | Back Directory | [Melting point ]
106-111°C | [Boiling point ]
527.7±50.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
solid | [pka]
-2.41±0.10(Predicted) | [InChI]
1S/C19H21ClF3N3O/c1-10(2)14-7-4-12(20)8-11(14)9-26(13-5-6-13)19(27)15-16(17(21)22)24-25(3)18(15)23/h4,7-8,10,13,17H,5-6,9H2,1-3H3 | [InChIKey]
JEFUQUGZXLEHLD-UHFFFAOYSA-N | [SMILES]
CC(C1=C(CN(C(C2=C(N(N=C2C(F)F)C)F)=O)C3CC3)C=C(Cl)C=C1)C |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Inhalation
Aquatic Acute 1
Aquatic Chronic 1
Repr. 2
Skin Sens. 1B |
| Hazard Information | Back Directory | [Description]
Isoflucypram is a new cereals fungicide. It as a low aqueous solubility and is not considered highly volatile. Under certain conditions the substance may be persistent in both soil and water systems. No major human health issues have been identified but it may be a skin sensitiser or cause skin irritation. It is toxic to aquatic systems but is not considered harmful to insect pollinators. | [Uses]
The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques.
| [Production Methods]
Isoflucypram is produced through a multi-fragment assembly route typical of recent SDHI fungicides, where the final molecule is built by coupling pre-constructed heterocyclic and halogenated aromatic units rather than through a single linear sequence. Commercial manufacture begins with synthesis of the pyridinyl-pyrimidinone core, formed through controlled cyclisation and halogenation steps. In parallel, producers prepare the fluorinated benzamide-type side chain, using established amide-forming and selective fluorination chemistry. These fragments are then joined via an activated acyl-coupling step, after which the crude product is purified, solvent stripped, and crystallised to achieve the required technical-grade solid. | [Mechanism of action]
Succinate Dehydrogenase Inhibitor (SDHI) | [Pesticide Type]
Fungicide |
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