| Identification | Back Directory | [Name]
TRX818 Sodium | [CAS]
1256037-62-3 | [Synonyms]
TRX818 Sodium
Foslinanib sodium
TRX818 Sodium salt | [Molecular Formula]
C16H14FNNaO6P | [MDL Number]
MFCD31725038 | [MOL File]
1256037-62-3.mol | [Molecular Weight]
389.25 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
TRX-818 is an anticancer compound.1,2 It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. 1 TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.2WARNING This product is not for human or veterinary use. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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