| Identification | Back Directory | [Name]
AI-10-49 | [CAS]
1256094-72-0 | [Synonyms]
CS-2138
AI-10-49
AI 1049;AI1049
2,2'-[Oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-1H-benzimidazole]
1H-Benzimidazole,2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[5-(trifluoromethoxy)-
1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-
2,2'-(5,5'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(6-(trifluoromethoxy)-1H-benzo[d]imidazole) | [Molecular Formula]
C30H22F6N6O5 | [MDL Number]
MFCD28900686 | [MOL File]
1256094-72-0.mol | [Molecular Weight]
660.52 |
| Chemical Properties | Back Directory | [Boiling point ]
790.3±70.0 °C(Predicted) | [density ]
1.478±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥ 16.53mg/mL in DMSO | [form ]
Powder | [pka]
8.33±0.10(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC50 value of 0.26 μM. AI-10-49 can be used for the research of leukemia[1]. | [in vivo]
AI-10-49 (200 mg/kg; per day) delays leukemia progression in mice[1]. | Animal Model: | Mice (Cbfb+/MYH11:Ras+/G12D leukemic cells)[1] | | Dosage: | 200 mg/kg | | Administration: | per day | | Result: | Reduced leukemia expansion in vivo and survived significantly long. |
| [References]
[1] Anuradha Illendula, et al. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347(6223):779-84. DOI:10.1126/science.aaa0314 |
|
|