| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, 2-[(1a,5a,6a)-6-[[(6-fluoro-2-quinolinyl)methyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-N-hydroxy- | [CAS]
1256448-47-1 | [Synonyms]
VRx-3996
Nanatinostat
Tractinostat)
CHR-3996
(Nanatinostat
NANATINOSTAT (CHR-3996)
5-Pyrimidinecarboxamide, 2-[(1a,5a,6a)-6-[[(6-fluoro-2-quinolinyl)methyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-N-hydroxy-
5-Pyrimidinecarboxamide, 2-[(1α,5α,6α)-6-[[(6-fluoro-2-quinolinyl)methyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-N-hydroxy- | [Molecular Formula]
C20H19FN6O2 | [MDL Number]
MFCD28986223 | [MOL File]
1256448-47-1.mol | [Molecular Weight]
394.4 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.12±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM[1]. | [storage]
Store at -20°C | [References]
[1] Moffat D, et al. Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. J Med Chem. 2010 Dec 23;53(24):8663-78. DOI:10.1021/jm101177s |
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