| Identification | Back Directory | [Name]
N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester | [CAS]
1256490-54-6 | [Synonyms]
-deoxy-3&rsquo
-fluoro-2&rsquo
N-[[P(S),2&rsquo
-methyl-P-phenyl-5&rsquo
-uridylyl]-L-alanine1-MethylethylEster
-O-[(1,1-dimethylethyl)dimethylsilyl]-2&rsquo
L-Alanine, N-[[P(S),2'R]-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester | [Molecular Formula]
C28H43FN3O9PSi | [MOL File]
1256490-54-6.mol | [Molecular Weight]
643.72 |
| Chemical Properties | Back Directory | [density ]
1.24±0.1 g/cm3(Predicted) | [solubility ]
Chloroform, Dichloromethane, Methanol | [form ]
Solid | [pka]
9.39±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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