| Identification | Back Directory | [Name]
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid | [CAS]
1256584-73-2 | [Synonyms]
Alecensa intermediate
Alectinib Impurity 14
Alectinib intermediate A
4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
2-(3-Iodo-4-ethylphenyl)-2-methylpropionic acid
Benzeneacetic acid, 4-ethyl-3-iodo-α,α-dimethyl-
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7
4-?Ethyl-?3-?iodo-?α,?α-?dimethylbenzeneaceti?c acid
4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid
2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid
(alectinib intermediate) | [Molecular Formula]
C12H15IO2 | [MDL Number]
MFCD22571222 | [MOL File]
1256584-73-2.mol | [Molecular Weight]
318.151 |
| Chemical Properties | Back Directory | [Boiling point ]
369.6±27.0 °C(Predicted) | [density ]
1.547±0.06 g/cm3(Predicted) | [pka]
4.32±0.11(Predicted) | [InChI]
InChI=1S/C12H15IO2/c1-4-8-5-6-9(7-10(8)13)12(2,3)11(14)15/h5-7H,4H2,1-3H3,(H,14,15) | [InChIKey]
RUVGXZCQYVEAKQ-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C(C1=CC=C(CC)C(I)=C1)(C)C |
| Hazard Information | Back Directory | [Uses]
2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. | [Synthesis]
2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid is prepared by reacting 4-Ethyl-α,α-dimethylbenzeneacetic acid with N-Iodosuccinimide in Acetic acid for 2h.
 |
|
|