| Identification | Back Directory | [Name]
2-Chloro-6-methoxyisonicotinonitrile | [CAS]
1256788-36-9 | [Synonyms]
2-Chloro-6-methoxyisonicotinonitrile
4-Pyridinecarbonitrile, 2-chloro-6-methoxy- | [Molecular Formula]
C7H5ClN2O | [MDL Number]
MFCD18204709 | [MOL File]
1256788-36-9.mol | [Molecular Weight]
168.58 |
| Chemical Properties | Back Directory | [Boiling point ]
230.4±40.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-1.34±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of 2-chloro-6-methoxypyridine-4-carbonitrile (25F): to a solution of 2,6-dichloro-4-cyanopyridine (24, 2.0 g, 11.6 mmol) in methanol (20 mL) was added sodium methanolate (628 mg, 11.6 mmol, 1.0 equiv). The reaction mixture was heated and stirred at 60°C for 6 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent. Water (300 mL) was added to the residue and the aqueous phase was extracted with ethyl acetate (3 × 25 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-chloro-6-methoxypyridine-4-carbonitrile (25F) as a clear viscous oil (1.95 g, quantitative yield).1H NMR (DMSO-d6, 200 MHz) δ 3.80 (s, 3H), 7.17 (s, 1H), 7.90 (s, 1H). | [References]
[1] Patent: WO2014/135617, 2014, A1. Location in patent: Page/Page column 85; 86 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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