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1257326-24-1

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1257326-24-1 Structure

1257326-24-1 Structure
IdentificationBack Directory
[Name]

4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
[CAS]

1257326-24-1
[Synonyms]

GSK-789472 HCl
GSK 789472 hydrochloride
5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
1-Phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride
[Molecular Formula]

C15H21N3O.HCl
[MDL Number]

MFCD18086910
[MOL File]

1257326-24-1.mol
[Molecular Weight]

295.808
Chemical PropertiesBack Directory
[Melting point ]

233-236°C
[storage temp. ]

Desiccate at RT
[solubility ]

Chloroform (Slightly, Sonicated), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
[Stability:]

Hygroscopic
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

GSK 789472 Hydrochloride is a dopamine D3 receptor (D3R) partial agonist. a specific D3DR antagonist and D2DR partial agonist.
[in vivo]

Dopamine D2 receptor agonist-3 (3 mg/kg, s.c.) shows high brain penetration (brain to blood ratio of 5.5) and Tmax of 0.5 h[1].

[IC 50]

D2 Receptor: 5 nM (EC50); D3 Receptor: >3.2 μM (EC50)
[storage]

Desiccate at RT
Spectrum DetailBack Directory
[Spectrum Detail]

4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one(1257326-24-1)1HNMR
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