| Identification | Back Directory | [Name]
DB-959Na | [CAS]
1258076-66-2 | [Synonyms]
T3D959
T-3D959
T-3D-959
DB-959Na
DB-959 (salt)
DB959 (salt),DB 959 (salt) | [Molecular Formula]
C25H28NNaO5 | [MDL Number]
MFCD32204303 | [MOL File]
1258076-66-2.mol | [Molecular Weight]
445.49 |
| Hazard Information | Back Directory | [Uses]
PPARδ/γ agonist 1 sodium is a chemically unique and brain penetrant dual PPAR delta/gamma agonist. PPARδ/γ agonist 1 sodium can be used for the research of Alzheimer’s disease[1]. | [in vivo]
PPARδ/γ agonist 1 sodium (1 mg/kg; i.g. once daily for 16 days) restores STZ-mediated impairments of motor function[1]. | Animal Model: | STZ-mediated Long Evans rats[1] | | Dosage: | 1 mg/kg | | Administration: | Oral gavage; 1 mg/kg once daily, for 16 days | | Result: | Improved performance in STZ-mediated rats and showed neuroprotective for both granule and Purkinje cells. |
| [storage]
4°C, away from moisture and light | [References]
[1] Tong M, et al. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38. DOI:10.3233/JAD-151013 |
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