| Identification | Back Directory | [Name]
2-chloro-4-cyano-6-fluoro-N-(2-((1R,2R)-2-fluorocyclopropanecarboxaMido)pyridin-4-yl)benzaMide | [CAS]
1258294-34-6 | [Synonyms]
TCJL37
Compound T4666
2-chloro-4-cyano-6-fluoro-N-(2-((1R,2R)-2-fluorocyclopropanecarboxaMido)pyridin-4-yl)benzaMide
2-chloro-4-cyano-6-fluoro-N-[2-[[(1R,2R)-2-fluorocyclopropanecarbonyl]amino]pyridin-4-yl]benzamide
2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
Benzamide, 2-chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]- | [Molecular Formula]
C17H11ClF2N4O2 | [MOL File]
1258294-34-6.mol | [Molecular Weight]
376.74 |
| Chemical Properties | Back Directory | [Boiling point ]
548.9±50.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.59±0.70(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide is a selective TYK2 inhibitor for the treatment of psoriasis. | [in vivo]
TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat[1]. | [IC 50]
Tyk2: 1.6 nM (Ki) | [storage]
Store at -20°C |
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BOC Sciences
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| Tel: |
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https://www.bocsci.com |
| Company Name: |
InvivoChem
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13549236410 |
| Website: |
https://www.invivochem.cn/ |
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