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1259028-99-3

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1259028-99-3 Structure

1259028-99-3 Structure
IdentificationBack Directory
[Name]

BTT 3033
[CAS]

1259028-99-3
[Synonyms]

BTT 3033
1-(4-Fluorophenyl)-N-methyl-N-(4-(3-phenylureido)phenyl)-1H-pyrazole-4-sulfonamide
1-(4-Fluoro-phenyl)-1H-pyrazole-4-sulfonic acid methyl-[4-(3-phenyl-ureido)-phenyl]-amide
1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
[Molecular Formula]

C23H20FN5O3S
[MDL Number]

MFCD28166480
[MOL File]

1259028-99-3.mol
[Molecular Weight]

465.5
Chemical PropertiesBack Directory
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

powder to crystal
[pka]

13.78±0.70(Predicted)
[color ]

White to Light yellow to Light orange
Safety DataBack Directory
[HS Code ]

2935.90.9500
Hazard InformationBack Directory
[Uses]

BTT 3033acts as a selective inhibitor of integrin, preventing platelet aggregation and potential application towards tumor suppression.
[in vivo]

BTT-3033 (oral administration, 10 mg/kg, at 24 h and 2 h before PAF induction) shows anti-inflammatory effects in mouse air pouch model[2].
BTT-3033 (oral administration, 10 mg/kg, at 48 ,24 and 2 h before ear swelling) shows anti-inflammatory effects in arachidonic acid-induced ear edema model[2].

Animal Model:PAF (platelet-activating factor)-induced mouse air pouch model[2]
Dosage:1, 10 mg/kg at 24 h and 2 h before PAF induction
Administration:Oral administration
Result:Reduced the infiltration of leukocytes by about 50% at 10 mg/kg.
Animal Model:Male DBA/1 mice (Pharmacokinetic assay)[2]
Dosage:10 mg/kg for a single dose
Administration:Oral administration
Result:Plasma levels: about 1 ng/mL at 24 h post-dose.
[IC 50]

α2β1: 130 nM (EC50)
[storage]

Store at +4°C
Spectrum DetailBack Directory
[Spectrum Detail]

BTT 3033(1259028-99-3)1HNMR
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