| Identification | Back Directory | [Name]
BTT 3033 | [CAS]
1259028-99-3 | [Synonyms]
BTT 3033
1-(4-Fluorophenyl)-N-methyl-N-(4-(3-phenylureido)phenyl)-1H-pyrazole-4-sulfonamide
1-(4-Fluoro-phenyl)-1H-pyrazole-4-sulfonic acid methyl-[4-(3-phenyl-ureido)-phenyl]-amide
1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide | [Molecular Formula]
C23H20FN5O3S | [MDL Number]
MFCD28166480 | [MOL File]
1259028-99-3.mol | [Molecular Weight]
465.5 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
powder to crystal | [pka]
13.78±0.70(Predicted) | [color ]
White to Light yellow to Light orange |
| Hazard Information | Back Directory | [Uses]
BTT 3033acts as a selective inhibitor of integrin, preventing platelet aggregation and potential application towards tumor suppression. | [in vivo]
BTT-3033 (oral administration, 10 mg/kg, at 24 h and 2 h before PAF induction) shows anti-inflammatory effects in mouse air pouch model[2].
BTT-3033 (oral administration, 10 mg/kg, at 48 ,24 and 2 h before ear swelling) shows anti-inflammatory effects in arachidonic acid-induced ear edema model[2]. | Animal Model: | PAF (platelet-activating factor)-induced mouse air pouch model[2] | | Dosage: | 1, 10 mg/kg at 24 h and 2 h before PAF induction | | Administration: | Oral administration | | Result: | Reduced the infiltration of leukocytes by about 50% at 10 mg/kg. |
| Animal Model: | Male DBA/1 mice (Pharmacokinetic assay)[2] | | Dosage: | 10 mg/kg for a single dose | | Administration: | Oral administration | | Result: | Plasma levels: about 1 ng/mL at 24 h post-dose. |
| [IC 50]
α2β1: 130 nM (EC50) | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
| Company Name: |
TCI Chemicals
|
| Tel: |
021-67121386, 800-988-0390 |
| Website: |
www.tcichemicals.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|