| Identification | Back Directory | [Name]
Benzoic acid, 3-[[[3-[[3-[4-(4-morpholinyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]methyl]thio]- | [CAS]
1259177-59-7 | [Synonyms]
Benzoic acid, 3-[[[3-[[3-[4-(4-morpholinyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]methyl]thio]- | [Molecular Formula]
C29H26N6O3S | [MOL File]
1259177-59-7.mol | [Molecular Weight]
538.62 |
| Chemical Properties | Back Directory | [Boiling point ]
854.7±75.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 50mg/mL | [form ]
Solid | [pka]
3.98±0.10(Predicted) | [color ]
Light brown to yellow |
| Hazard Information | Back Directory | [Uses]
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2]. | [References]
[1] Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334. DOI:10.3389/fnsyn.2021.650334
[2] Islam K, et al. A myosin?V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8. |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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