| Identification | Back Directory | [Name]
Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-(4-methylphenyl)- | [CAS]
1259532-01-8 | [Synonyms]
THCCC
PHCCC(4Me)
Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-(4-methylphenyl)- | [Molecular Formula]
C18H16N2O3 | [MOL File]
1259532-01-8.mol | [Molecular Weight]
308.33 |
| Hazard Information | Back Directory | [Description]
THCCC is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator and a PHCCC analog. | [Uses]
PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1]. | [References]
[1] Stephan Schann, et al. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators. J Med Chem. 2010 Dec 23;53(24):8775-9. DOI:10.1021/jm101069m |
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