| Identification | Back Directory | [Name]
Tipelukast | [CAS]
125961-82-2 | [Synonyms]
KCA 757
tipelukast
MN-001 (Tipelukast)
MN 001 (pharMaceutical)
Butanoic acid, 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-
4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)sulfanyl]propoxy]-2-propylphenoxy]butanoic acid | [Molecular Formula]
C29H38O7S | [MDL Number]
MFCD00886138 | [MOL File]
125961-82-2.mol | [Molecular Weight]
530.67 |
| Chemical Properties | Back Directory | [Melting point ]
82-84°C | [Boiling point ]
735.3±60.0 °C(Predicted) | [density ]
1.22 | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
4.59±0.10(Predicted) | [color ]
Off-White to Pale Beige |
| Hazard Information | Back Directory | [Uses]
Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model. | [Definition]
ChEBI: Tipelukast is an aromatic ketone. | [Biological Activity]
Tipelukast is a Leukotriene D4 (LTD4) receptor antagonist and an inhibitor of 5-lipoxygenase (5-LO) and also phosphodiesterases PDE3 and PDE4. It has been found to have antifibrotic and anti-inflammatory activity. Tipelukast has been investigated as a possible treatment for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). | [in vivo]
Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs[2]. | [IC 50]
LTD4: 6.41 (pA2, In guinea-pigs); LTE4: 6.45 (pA2, In guinea-pigs) |
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