| Identification | Back Directory | [Name]
TNP 351 | [CAS]
125991-51-7 | [Synonyms]
TNP 351
N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid
L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]- | [Molecular Formula]
C21H24N6O5 | [MDL Number]
MFCD00887508 | [MOL File]
125991-51-7.mol | [Molecular Weight]
440.45 |
| Hazard Information | Back Directory | [Uses]
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1]. | [References]
[1] F Itoh ,et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34(4):273-9. DOI:10.1007/BF00686032 |
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