| Identification | Back Directory | [Name]
t-Boc-N-amido-PEG1-NHS ester | [CAS]
1260092-55-4 | [Synonyms]
BocNH-PEG1-CH2CH2COONHS
Boc-N-PEG1-C2-NHS ester
t-Boc-N-amido-PEG1-NHS ester
2,5-Dioxopyrrolidin-1-yl 3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoate | [Molecular Formula]
C14H22N2O7 | [MDL Number]
MFCD20227793 | [MOL File]
1260092-55-4.mol | [Molecular Weight]
330.33 |
| Chemical Properties | Back Directory | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [form ]
Solid | [pka]
12.21±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG1-NHS ester is a PEG linker containing NHS ester and Boc-protected amine moieties. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Boc-N-PEG1-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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