| Identification | Back Directory | [Name]
4-Amino-2,6-difluorophenol | [CAS]
126058-97-7 | [Synonyms]
126058-97-7
4-AMINO-2,6-DIFLUOROPHENOL
4-amino-2,6-difluoropheneol
Phenol, 4-amino-2,6-difluoro-
3,5-Difluoro-4-hydroxyaniline
4-Amino-2,6-difluorophenol ISO 9001：2015 REACH | [Molecular Formula]
C6H5F2NO | [MDL Number]
MFCD03094493 | [MOL File]
126058-97-7.mol | [Molecular Weight]
145.11 |
| Chemical Properties | Back Directory | [Melting point ]
0°C | [Boiling point ]
0°C | [density ]
1.472±0.06 g/cm3(Predicted) | [Fp ]
0°C | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
7.72±0.23(Predicted) | [color ]
Brown | [CAS DataBase Reference]
126058-97-7 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-amino-2,6-difluorophenol from 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene: To a solution of 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene (5.3 g, 20 mmol) in ethanol (100 mL) was added 10% palladium/activated carbon (1.5 g). The reaction mixture was stirred overnight at room temperature and 1 atmosphere of hydrogen at 1 atm. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 4-amino-2,6-difluorophenol (2.9 g, 95% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.68 (br s, 1H), 6.19 (d, J = 10.8 Hz, 2H), 5.01 (s, 2H). | [References]
[1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 68 |
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