| Identification | Back Directory | [Name]
(24R)-3β-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-24-[2-O,6-O-bis(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]25-hydroxycucurbita-5-ene-11-one | [CAS]
126105-11-1 | [Synonyms]
11-O-Mogroside V
11-Oxomogroside V
Mogroside V, 11-oxo-
(24R)-3β-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-24-[2-O,6-O-bis(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]-25-hydroxycucurbit-5-en-11-one
(24R)-3β-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-24-[2-O,6-O-bis(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]25-hydroxycucurbita-5-ene-11-one
19-Norlanost-5-en-11-one, 24-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranosyl)oxy]-3-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-, (3β,9β,10α,24R)-
(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C60H100O29 | [MDL Number]
MFCD30496682 | [MOL File]
126105-11-1.mol | [Molecular Weight]
1285.42 |
| Chemical Properties | Back Directory | [density ]
1.51 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in methanol and water | [form ]
powder | [pka]
12.82±0.70(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Luo Han Guo. | [Uses]
Used for content determination/identification/pharmacological experiments, etc. | [Biological Activity]
11-oxo-mogroside V is a natural sweetener isolated from the fruit of bitter gourd Momordica grosvenori with strong antioxidant activity. It has a significant inhibitory effect on reactive oxygen species, acting on O2-, H2O2 and *OH, with EC50 of 4.79, 16.52 and 146.17 μg/mL, respectively. | [in vitro]
11-oxo-mogroside V shows a higher scavenging effect on O 2 - (concentration at which 50% of chemiluminescence intensity is inhibited [EC 50 ] =4.79 μg/mL) and H 2 O 2 (EC 50 =16.52 μg/mL) than those of mogroside V. It exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC 50 =3.09 μg/mL.11-oxo-mogroside V, a natural sweetener, isolated from the fruits of Momordica grosvenori , exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000, 500 and 100 mol ratio/TPA concentration, respectively). b> | [in vivo]
In the group treated with DMBA, TPA and 11-oxo-mogroside V, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion. | [target]
EC50: 4.79 μg/mL (O 2 - ), 16.52 μg/mL (H 2 O 2 ), 146.17 μg/mL (*OH) |
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