ChemicalBook--->CAS DataBase List--->1262417-51-5

1262417-51-5

Request For Quotation
1262417-51-5 Structure

1262417-51-5 Structure
IdentificationBack Directory
[Name]

NMS-P118
[CAS]

1262417-51-5
[Synonyms]

CS-2354
NMS-P118
NMS-P118; NMS-P 118; NMS P118
2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-6-fluoro-3-oxoisoindoline-4-carboxamide
2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide
2-[1-(4,4-difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide
1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-
[Molecular Formula]

C20H24F3N3O2
[MDL Number]

MFCD30533610
[MOL File]

1262417-51-5.mol
[Molecular Weight]

395.42
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: slightly soluble
[form ]

A crystalline solid
[color ]

White to off-white
[InChI]

InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)
[InChIKey]

ARYVAQSYRLZVQD-UHFFFAOYSA-N
[SMILES]

C1C2=C(C(C(N)=O)=CC(F)=C2)C(=O)N1C1CCN(C2CCC(F)(F)CC2)CC1
Hazard InformationBack Directory
[Uses]

2-[1-(4,4-Difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide is a nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. PARP-1 is involved with the signaling and repair of DNA and a target in oncology.
[in vivo]

NMS-P118 is a potent (KD=0.009 μM) PARP-1 inhibitor, showing 150-fold selectivity over PARP-2 (KD=1.39 μM). NMS-P118 possesses excellent pharmacokinetic profile and nearly complete oral bioavailability both in mice and rats. It proved to be highly efficacious in vivo both as single agent in MDA-MB-436 human breast cancer tumors and in combination with temozolomide in CAPAN-1 human pancreatic tumors growing as xenografts in the mouse. The compound is well tolerated at highly efficacious doses and is endowed with an excellent ADME profile[1].

[IC 50]

PARP-1: 9 nM (Kd); PARP-2: 1390 nM (Kd)
Spectrum DetailBack Directory
[Spectrum Detail]

NMS-P118(1262417-51-5)1HNMR
1262417-51-5 suppliers list
Company Name: Shanghai Jinyin Biological Technology Co., Ltd  Gold
Telephone: 021-20986266 18019349802
Website: https://www.chemicalbook.com/ShowSupplierProductsList1224855/0_EN.htm
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Telephone:
Website: www.boylechem.com
Company Name: Chembest Research Laboratories Limited  
Telephone: 021-20908456
Website: www.biochembest.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Telephone: 021-52996696，15000506266 15000506266
Website: http://www.bioll.com
Company Name: Guangzhou Zhiya Chemdrugs Co.,Ltd  
Telephone: 18122150900
Website: http://www.tiewill.com
Company Name: Shanghai Synchem Pharma Co., ltd  
Telephone: 21-619849051-1 18521059765
Website: www.synchem-pharma.com
Company Name: Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.  
Telephone: 027-65388397 18164111589
Website: http://www.hbclkc.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 15026964105
Website: www.shyuanye.com
Company Name: Shanghai Changyan Chem & Tech Co., Ltd.  
Telephone: 021-20242659 18930833303
Website: http://www.changyanchem.cn
Company Name: ShangHai Biochempartner Co.,Ltd  
Telephone: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
Telephone: 17801761073 18101056239
Website: http://www.solarbio.com
Company Name: Amadis Chemical Company Limited  
Telephone: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Resuperpharmtech Co., Ltd.  
Telephone: 02150565560; 17321237488
Website: http://www.resuperpharmtech.com
Company Name: Chuzhou KeMail Chemical Technology Co., Ltd  
Telephone: 0550-5196001 15000891977
Website: https://www.chemicalbook.com/ShowSupplierProductsList19947/0_EN.htm
Company Name: Shanghai Biopharmaleader Co., Ltd.  
Telephone: +86 18721201413
Website: www.biopharmaleader.com
Company Name: Shanghai BetterBioChem Co., Ltd.  
Telephone: +86-18017644823
Website: www.betterbiochem.com
Company Name: 3A Chemicals  
Telephone: 400-668-9898
Website: www.3achem.com
Company Name: Angel Pharmatech, Ltd.  
Telephone: 17317130613
Website: http://www.angelpharmatech.com
Tags:1262417-51-5 Related Product Information
6476-37-5 6336-34-1 328543-09-5 1825345-33-2 1140964-99-3 2337386-47-5