ChemicalBook--->CAS DataBase List--->1262780-97-1

1262780-97-1

1262780-97-1 Structure

1262780-97-1 Structure
IdentificationBack Directory
[Name]

Etelcalcetide
[CAS]

1262780-97-1
[Synonyms]

Etelcalcetide
AMG-416 (Velcalcetide)
D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine
[Molecular Formula]

C38H73N21O10S2
[MDL Number]

MFCD31735128
[MOL File]

1262780-97-1.mol
[Molecular Weight]

1048.25
Chemical PropertiesBack Directory
[density ]

1.58±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

2.01±0.10(Predicted)
[Sequence]

H-Cys(1)-OH,Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2(Disulfide bridge Cys1-(D-Cys1))/C(1),Ac-(D-C(1)-(D-A)-(D-R)-(D-R)-(D-R)-(D-A)-(D-R)-NH2(Disulfide bridge Cys1-(D-Cys1))
Hazard InformationBack Directory
[Uses]

N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl- D-Argininamide-L-cysteine Disulfide is a useful research chemical used in the treatment of chronic kidney disease-??mineral and bone disorder.
[Definition]

ChEBI: Etelcalcetide is an oligopeptide.
[Clinical Use]

Synthetic peptide calcimimetic agent:
Treatment of secondary hyperparathyroidism in patients on haemodialysis
[Drug interactions]

Potentially hazardous interactions with other drugs
Avoid with cinacalcet.
[Metabolism]

Etelcalcetide is biotransformed in blood by reversible disulphide exchange with endogenous thiols to predominantly form conjugate with serum albumin
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