| Identification | Back Directory | [Name]
7-Chlorokynurenic acid sodium salt | [CAS]
1263094-00-3 | [Synonyms]
7-CKA sodium salt
7-Chlorokynurenic acid sodium salt
7-Chloro-4-hydroxyquinoline-2-carboxylicacidsodiumsalt | [Molecular Formula]
C10H5CINNaO3 | [MDL Number]
MFCD12195840 | [MOL File]
1263094-00-3.mol | [Molecular Weight]
247.61 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at RT | [solubility ]
water: 100 mM | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble in water at 100mM | [InChI]
1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1 | [InChIKey]
IFZYIORLNGNLEI-UHFFFAOYSA-M | [SMILES]
[Na+].Clc1cc2[nH]c(c[c](c2cc1)=O)C(=O)[O-] |
| Hazard Information | Back Directory | [Uses]
7-Chlorokynurenic acid sodium salt is used as a Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is also used as an NMDA receptor antagonist and inhibitor of EAAT. | [Biological Activity]
Primary Target
NMDA receptors | [in vivo]
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3]. | [IC 50]
NMDA Receptor | [storage]
Desiccate at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|