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1264015-76-0

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1264015-76-0 Structure

1264015-76-0 Structure
IdentificationBack Directory
[Name]

t-Boc-N-amido-PEG6-Tos
[CAS]

1264015-76-0
[Synonyms]

NHBoc-PEG6-Tos
t-Boc-N-amido-PEG6-Tos
[Molecular Formula]

C24H41NO10S
[MDL Number]

MFCD31803899
[MOL File]

1264015-76-0.mol
[Molecular Weight]

535.65
Chemical PropertiesBack Directory
[Boiling point ]

627.9±55.0 °C(Predicted)
[density ]

1.159±0.06 g/cm3(Predicted)
[pka]

12.23±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

t-Boc-N-amido-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

t-Boc-N-amido-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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