| Identification | Back Directory | [Name]
eponemycin | [CAS]
126509-46-4 | [Synonyms]
eponemycin
Heptanamide, N-[(1S)-1-(hydroxymethyl)-2-[[(1S)-1-[[(2R)-2-(hydroxymethyl)-2-oxiranyl]carbonyl]-3-methyl-3-buten-1-yl]amino]-2-oxoethyl]-6-methyl- | [Molecular Formula]
C20H34N2O6 | [MDL Number]
MFCD00884628 | [MOL File]
126509-46-4.mol | [Molecular Weight]
398.49 |
| Hazard Information | Back Directory | [Uses]
Eponemycin is an antibiotic that exhibits antitumor activity. Eponemycin exhibits cytotoxicity in cancer cells B16-F10, L1210, P388 and HCT-116 with IC50 of 0.0017, 0.01, 0.031 and 0.0097 μg/mL, respectively. Eponemycin inhibits the DNA synthesis in B16-F10 and Mitomycin C with IC50 of 0.1 μg/mL and 0.41 μg/mL[1]. | [References]
[1] Sugawara K, et al., Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity. J Antibiot (Tokyo). 1990 Jan;43(1):8-18. DOI:10.7164/antibiotics.43.8 |
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