| Identification | Back Directory | [Name]
althiomycin | [CAS]
12656-40-5 | [Synonyms]
116-A
Matamycin
NS-102809
Nsc 102809
althiomycin
N-[1-[4-[(2,5-Dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)carbonyl]-4,5-dihydrothiazol-2-yl]-2-hydroxyethyl]-2-[(hydroxyimino)methyl]-4-thiazolecarboxamide
4-Thiazolecarboxamide, N-[1-[(4S)-4-[(2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)carbonyl]-4,5-dihydro-2-thiazolyl]-2-hydroxyethyl]-2-[(E)-(hydroxyimino)methyl]- | [Molecular Formula]
C16H17N5O6S2 | [MDL Number]
MFCD01681520 | [MOL File]
12656-40-5.mol | [Molecular Weight]
439.47 |
| Chemical Properties | Back Directory | [Melting point ]
172-174 °C (decomp) | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
A crystalline solid | [pka]
9.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL. | [References]
[1] Gerc, et al. The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One 7(9), e44673 (2012). |
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