| Identification | Back Directory | [Name]
(R)-Methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate fumarate | [CAS]
126766-43-6 | [Synonyms]
126766-43-6
(R)-(-)-GR103545 fumarate
(R)-Methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate fumarate | [Molecular Formula]
C23H29Cl2N3O7 | [MDL Number]
MFCD00902108 | [MOL File]
126766-43-6.mol | [Molecular Weight]
530.4 |
| Hazard Information | Back Directory | [Description]
GR-103545 is a reference and non-radio labeled agent. The radio-labeled 11C-GR103545 is a promising PET radiotracer for imaging the κ-OR. | [Uses]
GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). 11GR103545 is a radiotracer for imaging κ-OR in vivo[1][2]. | [References]
[1] Hayes AG, et, al. A series of novel, highly potent and selective agonists for the kappa-opioid receptor. Br J Pharmacol. 1990 Dec;101(4):944-8. DOI:10.1111/j.1476-5381.1990.tb14185.x
[2] Talbot PS, et, al. 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons. J Nucl Med. 2005 Mar;46(3):484-94. PMID:15750163 |
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