| Identification | Back Directory | [Name]
5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone | [CAS]
1268140-15-3 | [Synonyms]
5,7,3'-TRIHYDROXY-4'-METHOXY-8-P
5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone
(2S)-5,7,3'-trihydroxy-4'-methoxy-8-(3''-methylbut-2''-enyl)-flavonone
5,7-Dihydroxy-2-(3-hydroxy-4-Methoxyphenyl)-8-(3-Methylbut-2-en-1-yl)chroMan-4-one
(2S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-, (2S)- | [Molecular Formula]
C21H22O6 | [MDL Number]
MFCD27920545 | [MOL File]
1268140-15-3.mol | [Molecular Weight]
370.4 |
| Chemical Properties | Back Directory | [Boiling point ]
616.0±55.0 °C(Predicted) | [density ]
1.308±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.67±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone (compound 1), a flavonoid, is a potent ABCG2 inhibitor with an IC50 of 6.6 μM[1]. | [Definition]
ChEBI: A trihydroxyflavanone that is hesperetin substituted by a prenyl group at position 8. Isolated from Macaranga conifera, it exhibits inhibitory activity against breast cancer resistance protein. | [References]
[1] Muhammad Ali Versiani, et al. Flavonoids from Eight Tropical Plant Species That Inhibit the Multidrug Resistance Transporter ABCG2. J Nat Prod. 2011 Feb 25;74(2):262-6. DOI:10.1021/np100797y |
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