| Identification | Back Directory | [Name]
PX 102 | [CAS]
1268245-19-7 | [Synonyms]
PX 102
CPD1220
Benzoic acid, 4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]- | [Molecular Formula]
C29H22Cl3NO4 | [MDL Number]
MFCD32204663 | [MOL File]
1268245-19-7.mol | [Molecular Weight]
554.85 |
| Hazard Information | Back Directory | [Uses]
PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy[1]. | [References]
[1] Deuschle U, et al., FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012;7(10):e43044. DOI:10.1371/journal.pone.0043044 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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